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Photo 1 of 48: Italianate home featuring a front yard, brick siding, a ceiling fan, and a chimney
Italianate home featuring a front yard, brick siding, a ceiling fan, and a chimney
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221 W Saint Joseph Street, Perryville, MO 63775

Fifth Principal Meridian · Perry County

Key Facts

6Beds
5Baths
3,143Sq Ft
1910Year Built
0.37Lot (acres)

Description

Looking for a turn key, fully operational business in the heart of Perryville? The Mediterranean House presents a rare opportunity to own a luxury property designed to host unforgettable stays and events. Currently operating as a successful and versatile venue, this property is well suited for use as an Airbnb, bed and breakfast, or a destination for corporate retreats, wellness or yoga getaways, and private events. The home features six beautifully appointed bedrooms, four full bathrooms, and one half bathroom, offering ample accommodations for guests. A commercial grade kitchen equipped with stainless steel appliances is ready to support culinary experiences, from baking and cooking workshops to catered events. All furniture stays, including antique furnishings, bedroom suites, dining room suites, etc. With its flexible layout and elegant setting, The Mediterranean House is ideal for bridal and baby showers, birthday celebrations, intimate gatherings, or larger hosted events. This is a truly turn key business opportunity, ready for immediate operation, offering the space, functionality, and charm to bring a wide range of visions to life.

Property Information

Property Type

Residential

Sub-Type

Single Family Residence

Structure Type

House

Year Built

1910

Living Area

3,143 sq ft

Lot Size

0.37 acres

Lot Dimensions

73x7x171x68x134x12x318

Days on Market

1

MLS® Listing#

25081439

Property Features

Interior

Beamed CeilingsBuilt-in FeaturesNatural Woodwork

Appliances

Stainless Steel Appliance(s)DishwasherOvenRange

Cooling

Wall/Window Unit(s)

Heating

ElectricNatural GasVaries by Unit

Flooring

Ceramic TileHardwood

Fireplace

BedroomLiving Room

Basement

Full

Parking

ConcreteDrivewayGravelOff Street

Laundry

In Basement

Patio

CoveredFront PorchPatio

Fencing

None

Lot Features

Back YardFront YardLandscaped

Construction

Brick

Roof

AsphaltShingle

Utilities

Electricity ConnectedSewer ConnectedWater Available

Sewer

Public Sewer

Water Source

Public

Schools

Elementary:
Perryville Elem.
Middle:
Perry Co. Middle
High:
Perryville Sr. High

Financial Details

HOA

None

Annual Taxes

$4,078

Tax year 2025

Parcel Number

10-4.0-019-002-003-112.00000

Affordability Calculator

$112,000

Estimated monthly payment

$2,981/mo

Principal $448,000 · Est. interest $625,000 over 30 yrs

Neighborhood Market Statistics

How this home compares to active listings in Perryville, MO

$300,000
Median Listing Price
60
Median Days on Market
1,738
Median Sq Ft
$169
Median Price / Sq Ft
28
Active Listings
  • This home’s price is 87% above the area median.
  • Its price per sq ft is 5% above the area median.

Market statistics compiled from active EXIT Realty® and MLS listings in Perryville, MO.

Location

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Nearby Homes

Similar Homes Nearby

Similar Home Values

Comparable nearby listings and their asking prices.

AddressPriceBedsBathsSq Ft
97 PCR 522, Perryville, MO$599,900533,090

Moving Cost Estimate

EXIT Agents in Perryville

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Listing Courtesy: EDGE Realty ERA Powered - 5733358111

Presented by: Jacob Fish

Based on information submitted to the MLS GRID as of 2025-12-16 . All data is obtained from various sources and may not have been verified by broker or MLS GRID. Supplied Open House Information is subject to change without notice. All information should be independently reviewed and verified for accuracy. Properties may or may not be listed by the office/agent presenting the information.

The data relating to real estate for sale on this web site comes in part from the Internet Data Exchange (IDX) program of one or more Multiple Listing Services (MLS). Listing information is deemed reliable but is not guaranteed accurate. Copyright © EXIT Realty® and respective MLS providers.

Data provided by Southeast Missouri REALTORS. MLS® Listing#25081439. © 2026EXIT Realty®. All rights reserved.