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Photo 1 of 46: Italianate home featuring a front yard, brick siding, a ceiling fan, and a chimney
Italianate home featuring a front yard, brick siding, a ceiling fan, and a chimney
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221 W Saint Joseph Street, Perryville, MO 63775

Fifth Principal Meridian · Perry County

Key Facts

3,143Sq Ft
1910Year Built
0.37Lot (acres)
2Stories

Description

Looking for a turn key, fully operational business in the heart of Perryville? The Mediterranean House presents a rare opportunity to own a luxury property designed to host unforgettable stays and events. Currently operating as a successful and versatile venue, this property is well suited for use as an Airbnb, bed and breakfast, or a destination for corporate retreats, wellness or yoga getaways, and private events. The home features six beautifully appointed bedrooms, four full bathrooms, and one half bathroom, offering ample accommodations for guests. A commercial grade kitchen equipped with stainless steel appliances is ready to support culinary experiences, from baking and cooking workshops to catered events. All furniture stays, including antique furnishings, bedroom suites, dining room suites, etc. With its flexible layout and elegant setting, The Mediterranean House is ideal for bridal and baby showers, birthday celebrations, intimate gatherings, or larger hosted events. This is a truly turn key business opportunity, ready for immediate operation, offering the space, functionality, and charm to bring a wide range of visions to life.

Property Information

Property Type

Commercial Sale

Year Built

1910

Stories

2

Living Area

3,143 sq ft

Lot Size

0.37 acres

Ownership

Private

Days on Market

1

MLS® Listing#

25081443

Property Features

Appliances

Stainless Steel Appliance(s)DishwasherOvenRangeRefrigerator

Cooling

Wall/Window Unit(s)

Heating

Natural Gas

Flooring

Ceramic TileHardwood

Laundry

In Basement

Fencing

None

Construction

Brick

Utilities

Electricity AvailableSewer AvailableWater Available

Financial Details

Annual Taxes

$4,078

Tax year 2025

Parcel Number

10-4.0-019-002-003-112.00000

Affordability Calculator

$112,000

Estimated monthly payment

$2,981/mo

Principal $448,000 · Est. interest $625,000 over 30 yrs

Neighborhood Market Statistics

How this home compares to active listings in Perryville, MO

$300,000
Median Listing Price
60
Median Days on Market
1,738
Median Sq Ft
$169
Median Price / Sq Ft
28
Active Listings
  • This home’s price is 87% above the area median.
  • Its price per sq ft is 5% above the area median.

Market statistics compiled from active EXIT Realty® and MLS listings in Perryville, MO.

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EXIT Agents in Perryville

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Listing Courtesy: EDGE Realty ERA Powered - 5733358111

Presented by: Jacob Fish

Based on information submitted to the MLS GRID as of 2025-12-16 . All data is obtained from various sources and may not have been verified by broker or MLS GRID. Supplied Open House Information is subject to change without notice. All information should be independently reviewed and verified for accuracy. Properties may or may not be listed by the office/agent presenting the information.

The data relating to real estate for sale on this web site comes in part from the Internet Data Exchange (IDX) program of one or more Multiple Listing Services (MLS). Listing information is deemed reliable but is not guaranteed accurate. Copyright © EXIT Realty® and respective MLS providers.

Data provided by Southeast Missouri REALTORS. MLS® Listing#25081443. © 2026EXIT Realty®. All rights reserved.